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Zambia $964,980.70 PEPFAR a cluster-randomized trial of the SAMBA POC virologic test to improve outcomes of HIV-infected children in Zambia NIAID Braithwaite 99970 NYU/Ampath Implementation science to optimize HIV prevention in East Africa PEPFAR programs. Uganda/Kenya/ Tanzania $889,221.45 PEPFAR create a model that will simulate the HIV epidemic in east Africa, taking into account person-to-person HIV transmission, in order to evaluate the benefit and value of retention-in-care interventions in east Africa NIAID Havlir 99959 UCSF Initiate ART: Sreamlined ART Start Strategy (START) Uganda $963,331.52 PEPFAR evaluate the effectiveness of a multi-component Streamlined ART Start Strategy (START) based on an empirically validated model of change that deploys 1) portable point of care (POC) CD4 testing and adapted counseling to enable ART start, 2) dissemination of information through education that predisposes provider behavior and 3) feedback reporting on FTIs that reinforces uptake of ART NIAID Frenkel 100037 Seattle Child Drug resistance testing in Kenya to improve ART suppression of HIV replication Kenya $934,684.53 PEPFAR An inexpensive simple assay (oligonucleotide ligation assay (OLA)) to detect HIV drug-resistance will be implemented in Kenya. We will study the benefits conferred by this assay to improving infected individuals health, and compare the overall cost of using to not using this test. NIAID El Sadr 100059 Columbia Link4Health: a combination strategy for linkage and retention: Swaziland Swaziland $962,976.40 OAR two-arm cluster site-randomized trial to compare the effectiveness of a novel combination package of evidence-based interventions, the combination intervention strategy (CIS), compared to standard of care (SOC) on linkage and retention of HIV-positive patients from point of testing to retention in care NIAID Bailey 99953 U-IL/UNIM integration of infant male circumcision with community health services in Kenya Kenya $964,748.14 PEPFAR To provide the evidence-base necessary to guide implementation of IMC services, we propose a simultaneous, prospective comparison of two sustainable, scalable models of IMC service delivery NIAID Rosen 100015 Boston U Rapid initiation of ART to promote early HIV/AIDS treatment in South Africa $331,692.70 OAR The study is designed as an unblinded randomized strategy trial comparing the current standard of care to a rapid ART initiation strategy for outpatient adults and pregnant women who come to a South African clinic for an HIV test and are eligible for ART NIAID Howard 100044 Columbia A combination intervention package for Isoniazid preventive therapy in Ethiopia Ethiopia $632,048.95 PEPFAR ENhance Initiation and Retention in IPT Care for HIV Study (ENRICH Study), which aims to evaluate the effectiveness of a combination intervention package (CIP) versus standard of care (SOC), to improve IPT initiation, adherence, and completion among HIV-infected individuals enrolled in HIV care at health centers in Ethiopia NCI Campbell 100026 U CO Strategies to improve KS Outcomes in Zimbabwe Zimbabwe $965,000.00 PEPFAR develop evidence-based, cost-efficient approaches to improve detection and management of AIDS-KS and its related symptoms in low resource environments, and to evaluate the implementation of these approaches in primary care settings in urban and rural communities in Zimbabwe NICHD Abrams 99951 Columbia ART in pregnant women in SA South Africa $768,676.54 PEPFAR "fast tracking" ART initiation in pregnancy, combines strategies to address the key health systems, clinical, and patient education and adherence issues that currently act as barriers to rapid ART initiation in pregnancy - HIV viral suppression at the time of delivery as the primary outcome. Secondary aims include the transmission of HIV from mother-to-child and retention in care through 6 months postpartum, as well as the acceptability and costeffectiveness of this intervention NICHD Pfeiffer 99987 UW Among HIV-positive pregnant women in central MZ Mozambique $593,311.92 PEPFAR develop and test a pilot intervention in central Mozambique to implement the new WHO guidelines and increase the proportion of HIV-positive pregnant women in target ANC clinics who start ART prior to delivery, without reducing ART adherence. The intervention will emphasize a "test and treat" approach. NIMH Blattner 100101 UMD TRUST Nigeria $964,909.29 PEPFAR TRUST is that Network-based recruitment to expand engagement of Nigerian MSM that links clients to combination prevention and comprehensive HIV and medical services delivered at community-trusted venues achieves measurable behavioral change, and durable high quality clinical outcomes NIMH Wagner 99884 RAND Task shifting model of depression treatment to unleash HIV Public Health Benefits $392,755.00 PEPFAR We will test an algorithm-based, nurse-driven model for managing antidepressant treatment. TOTAL per YEAR $11,943,595.64 OAR Funds $1,945,256.66 PEPFAR Funds $9,998,338.98 RFA HD-12-210: NIH/PEPFAR Collaboration for Advancing Implementaton Science in Prevention of Maternal-Child HIV Transmission (PMTCT) R01 RFA HD-12-210: NIH/PEPFAR Collaboration for Advancing Implementaton Science in Prevention of Maternal-Child HIV Transmission (PMTCT) R01 IC PI Grant # Institution Title Country