Attachment

GI Lesions Gastrointestinal (Gl) lesions that are not typically associated with filoviral disease in NHPs Lesions not seen in healthy NHP toxicology studies The lesions were more severe and occurred nearly exclusively in animals from the groups that received favipiravir Distal small intestine, cecum, colon Foci and transmural areas of hemorrhage and necrosis, adhesions, stringy white material Hard feces Material in stomach and intestines that appeared similar to favipiravir Potential complicating factors ¢ Dehydration * Opioid effect of sedation on GI tract ¢ Stress of BID sedation Confidential