Phone call

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In context

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1. 2020-01-31 17:23 Jeremy Farrar
   Tony Really would like to speak with you this evening It is 10pm now UK Can you phone me on Jeremy Wellcome exists to improve health by helping great ideas to thrive. We support researchers, we take on big health challenges, we campaign for better science, and we help everyone get involved with science and health research. We are a politically and financially independent foundation. The Wellcome Trust is a charity registered in England and Wales, no. 210183. Its sole trustee is The Wellcome Trust Limited, a company registered in England and Wales, no. 2711000 (whose registered office is at 215 Euston Road, London NW1 2BE, UK) WV>
2. 2020-01-31 17:57 Jeremy Farrar open
   Thanks Tony Can you phone Kristian Anderson He is expecting your call now. The people involved are: Kristian Anderson https://www.scripps.edu/faculty/andersen/ Bob Garry https://medicine.tulane.edu/departments/microbiology-immunology-tulane-cancer-center/faculty/robert-fgarry-jr-phd Eddie Holmes https://sydney.edu.au/science/about/our-people/academic-staff/edward-holmes.html
3. 2020-01-31 19:39 Anthony S. Fauci open
   Jeremy: I just got off the phone with Kristian Anderson and he related to me his concern about the Furine site mutation in the spike protein of the currently circulating 2019-nCoV. I told him that as soon as possible he and Eddie Holmes should get a group of evolutionary biologists together to examine carefully the data to determine if his concerns are validated. He should do this very quickly and if everyone agrees with this concern, they should report it to the appropriate authorities. I would imagine that in the USA this would be the FBI and in the UK it would be MI5. It would be important to quickly get confirmation of the cause of his concern by experts in the field of coronaviruses and evolutionary biology. In the meantime, I will alert my US. Government official colleagues of my conversation with you and Kristian and determine what further investigation they recommend. Let us stay in touch. Best regards, Tony Anthony S. Fauci, MD Director National Institute of Allergy and Infectious Diseases 7PM ' dential < acipient. other stc for any statements made that are the sender's representatives. ny (NIH/NIAID) Building 31, Room 7A-03 31 Center Drive, MSC 2520 National Institutes of Health Bethesda, MD 20892-2520 The information in this e-mail and any of its attachments is confidential and may contain sensitive information. It should not be used by anyone who is not the original intended recipient. If you have received this e-mail in error please inform the sender and delete it from your mailbox or any other storage devices. The National Institute of Allergy and Infectious Diseases (NIAID) shall not accept liability for any statements made that are the sender's own and not expressly made on behalf of the NIAID by one of its representatives.
4. 2020-01-31 20:16 John Mascola open
   Tony, I will track and will review data on the "furin cleavage site" of 2019-nCoV. This is the site that is analogous to the furin cleavage site between gp120 and gp41 of HIV. It generally consists of a short series of basic AA (so Arg, Lys). For most type 1 viral surface proteins (like HIV), the cleavage event is necessary for the trimeric protein to fold into its native configuration. But for CoV family, there is a lot of natural variation at this site - so I would need to hear more details to understand the concern by Kristian and others. John
5. 2020-01-31 21:45 Anthony S. Fauci open
   The story gets complicated. I will forward to you a very recent article by Jon Cohen that will shed some light. Tony

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