A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
-
July 1, 2022 Global - 543,352,927/6,331,059; USA - 87,298,343/1.012,767 Tested Ag negative today!! In April 2022, among people ages 50 years and older, unvaccinated people had: compared to people vaccinated with a primary series and two or more booster doses.** Among people ages 50 years and older, vaccinated people with a primary series and one booster dose had: 4X Risk of Dying from COVID-19 Source: CDC COVID- 19 Response, Epidemiology Task Force, Surveillance & Analytics Team, Vaccine Breakthrough Unit compared to people vaccinated with a primary series and two or more booster doses.** : 30,000 7 25,000 : so.000 United Kingdom 10,000 5,000 . Apr 15, 2022
-
July 2, 2022 2nd day in a row Ag negative Noteworthy is that Senator John Kennedy (R-LA) despite his seeming antagonism of me sent me a very nice, handwritten "get well soon" note. Monkeypox problem growing..... Global.health: 6178 confirmed MPX cases in 67 non-endemic countries; 51 suspected. 459 in USA
-
July 2, 2022 *****Important debate going on that relates back to the conflict that I had with the CDC I was concerned that they did not call for antigen testing following infection before someone is able to go back out into society. The president got infected, went on Paxlovid, and then rebounded. And so the question is when can he go back into society. Since he is the president and we test them every day he is staying isolated until his antigen test reverts to negative. At the same time, a number of papers including in the NEJM have shown that the median time of reversion to negative antigen test is actually five days and many people stay positive until day 8,9,10 and beyond. The CDC recommendations say that after five days since no requirement is made for testing (which I was very much against this decision and caused a ruckus by disagreeing with the CDC many months ago), A person can go out into society after five days with the mask so long as they have no symptoms. And after 10 days, if they still have no symptoms they can take their mask off. This obviously Will lead to people going out into society who are still antigen positive and are likely spreading the virus. That was my original concern when I disagreed with the CDC. BA.5 now 86% of isolates in USA: % Viral Lineages Among Infections 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% v 5/7/22 5/14/22 §/21/22 5/28/22 6/4/22 6/18/22 6/25/22 7/2/22 7/9/22 7/16/22 7/23/22 7/30/22 USA WHO label Lineage # USClass %Total 95%PI Omicron BAS VOC 85.5% 83.8-87.0% BA.4 VOC 7.7% 7.0-8.5% BA4.6 VOC 41% 3.2-5.4% BA.2.12.1 VOC 26% 2.4-2.8% BA.2 voc 0.1% 0.1-0.1% B.1.1.529 voc 0.0% 0.0-0.0% BA.1.1 voc 0.0% 0.0-0.0% Delta B.1.617.2 VBM 0.0% 0.0-0.0% Other Other* 0.0% 0.0-0.0% * Enumerated lineages are US VOC and lineages circulating above 1% nationally in at least one week period. "Other" rep ts the aggregati lineages which are circulating <1% nationally during all weeks di ** These data include Nowcast estimates, which are modeled projections that may differ from weighted estimates generated at later dates # AY.1-AY.133 and their sublineages are aggregated with B.1.617.2. BA.1, BA.3 and their sublineages (except BA.1.1 and its sublineages) are aggregated with B.1.1.529. For regional data, BA.1.1 and its sublineages are also aggregated with B.1.1.529, as they currently cannot be reliably called in each region. Except BA.2.12.1, BA.2 sublineages are aggregated with BA.2. Except BA.4.6, af DA £ arn annranantiad eublinananase Af DA A aca Dawn.Oconnell@hhs.gov>; alcido, Dori A. EOP/WHO sa.L.Barclay@who.eop.gov A lot of activity working with Rob at the FDA and Ashish and CDC to get the right messaging about recommendations for the booster in the fall. The FDA would like to say that the bivalent BA.5 boost is significantly better then the mono valent ancestral strain boost. There is a lot of pushback from the immunology community led by John Moore saying that the bivalent BA.5 boost is only marginally better then the monovalent ancestral strain. The data is somewhat confusing as explained below in an e-mail from Rick Koup to me. The debate is whether to ask people who are otherwise that low to moderate risk to get vaccinated now with the ancestral strain will wait until September when a supposedly much better boost is available. Most of us have no problem with low risk people waiting, however, I and others are concerned about overselling that the bivalent boost is much better then the ancestral boost, which is not the case I will list a couple of emails below that outline the dilemma:
-
Jul 2, 2022 FDA gave EUA to BA.5 bivalent boosts and USG has ordered 170 million doses to be administered starting next week. As usual some concern among some "talking heads" about doing this from Paul Offit who generally feels that most people really do not need boosters to a milder John Moore who is concerned about the immunology of a poor response. Eric Topol gives the pros and cons today in his usual blog: Pluses Minuses First updated vaccine since 2020 No BA.5 variant specific human neutralizing antibody data Matches current BA.5 wave and current related variants (BA.4.6) Unknown if it will have better clinical outcomes than original booster Made at scale in ~2 months, fulfilling mRNA platform promise May add to booster hesitancy, lack of uptake, only 32% of population Relies on flu vaccine updating strategy from mice data used for decades SARS-CoV-2 is not influenza Prior human data for immune response to BA.1 and Beta variants Potential of imprinting to diminish effect, would BA.5 monovalent vaccine be better? Shows agility of FDA Lack of input by VRBPAC Potential to lessen infections and transmission May not impact infections and transmission reading whole article): Recent article in Salon (worthwhile reading whole article): COMMENTARY Farewell Dr. Fauci: How the right turned a national hero into a villain in service of Donald Trump The right's attack on science is the most dangerous of its cynical power plays. Fauci is just collateral damage
-
2022-07-03 00:00
Anthony S. Fauci
July 3, 2022 UK reporting anther "concerning variant - BA. 2.175
-
July 4, 2022 ot IS are o USA. I had a very relaxed day today. Went on a nice walk. After that we hung around the house and towards the evening we went fishing on the canal but, as usual, we didn't catch anything. Yesterday was a fun day in that not only did we go for a good walk, but I also threw the baseball around in preparation for my trip to Seattle, and then Brett and I shut around some baskets at Horace Mann school. Next week is going to be a tough week in that there's a lot of stuff going on in addition
-
July 5, 2022 Global USA Recent article in The Atlantic by Cary Gross and Zeke Emanuel criticized the NIH for not moving quickly or effectively enough on research on COVID. Larry Tabak wrote a letter in strong response: THE CONVERSATION Letter: The NIH Has Responded Forcefully to COVID-19 The nation's leading health-research agency, its acting director writes, has moved with unprecedented speed against a global threat.
-
July 6, 2022 Global USA Activists including James Krellenstein, Gregg Gonsalves and Peter Staley among others are getting agitated at HHS and NSC (Raj Panjabi) for the lack of Jynneos (MVA - Bavarian Nordic) for PrEP for Monkeypox for the Gay community (MSM) MPX cases increasing greatly in USA especially in DC, NYC and Chicago
-
July 7, 2022 BA.2.75 increasing in Australia, India and several other countries. Some cases in USA. Watching it closely ons/essays/pepfar.html County-level COVID-19 Community Levels