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Fauci Awards Package (Redacted), p.57 · fauci_awards:email:00089

Date: 2021-02-08 10:06
Type: email · email
sender: Drew Weissman
to: Anthony M Fauci
Topics: Vaccines Awards, honoraria and recognition Therapeutics and treatments

This text appears inside a quoted reply chain — it is evidence that the message was circulating, not necessarily a new message.

Tony, Hope all is well. I wanted to alert you to some new data we generated with our nucleoside-modified mRNA-LNP vaccine. I attached a current version of a supplement request that has all of the new data. I have been working with a maternal-fetal researcher and we observed that using a dose 100-fold higher than current vaccines and given IV, the mRNA-LNPs go to the placenta and fetus, measured by translation of the mRNA and cause an immune response in the amniotic fluid. In non-pregnant female mice, the uterus and ovaries take up mRNA-LNPs and translate the mRNA. We are repeating these studies with human dose levels of mRNA-LNPs given IM and are waiting to release the findings until these studies are completed I have spoken to the FDA, Moderna, BioNTech/Pfizer, and DARPA, who is doing a clinical trial with higher doses IV, about these findings. I have also spoken to Mary Marovich and Michael Pensiero, our program officer for 2 clinical trials for HIV mRNA-LNP vaccines. He will get us supplementary funding to investigate these findings. Thank you for doing the Rosenstiel award. Take care. Drew Drew Weissman, M.D., Ph.D. Perelman School of Medicine at the University of Pennsylvania Philadelphia, PA

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

Statement	Grade	Attribution	Stance
I have been working with a maternal-fetal researcher and we observed that using a dose 100-fold higher than current vaccines and given IV, the mRNA-LNPs go to the placenta and fetus, measured by translation of the mRNA and cause an immune response in the amniotic fluid.	own voice, substantive	speaker_own	asserts
We are repeating these studies with human dose levels of mRNA-LNPs given IM and are waiting to release the findings until these studies are completed I have spoken to the FDA, Moderna, BioNTech/Pfizer, and DARPA, who is doing a clinical trial with higher doses IV, about these findings.	own voice, substantive	speaker_own	asserts
I have also spoken to Mary Marovich and Michael Pensiero, our program officer for 2 clinical trials for HIV mRNA-LNP vaccines.	own voice, substantive	speaker_own	asserts

Statement

Grade

Attribution

Stance

I have been working with a maternal-fetal researcher and we observed that using a dose 100-fold higher than current vaccines and given IV, the mRNA-LNPs go to the placenta and fetus, measured by translation of the mRNA and cause an immune response in the amniotic fluid.

own voice, substantive

speaker_own

asserts

We are repeating these studies with human dose levels of mRNA-LNPs given IM and are waiting to release the findings until these studies are completed I have spoken to the FDA, Moderna, BioNTech/Pfizer, and DARPA, who is doing a clinical trial with higher doses IV, about these findings.

own voice, substantive

speaker_own

asserts

I have also spoken to Mary Marovich and Michael Pensiero, our program officer for 2 clinical trials for HIV mRNA-LNP vaccines.

own voice, substantive

speaker_own

asserts