A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
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So gain-of-function, you're talking about a live virus.
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What would they be spraying?
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They're spraying a small, double-stranded RNA molecule that induces host innate immune responses. That's host defense molecules that prevent virus infection, or limit virus replication.
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Why are they trying to do these two DC.Scheduling@LexitasLegal.com different tasks? So they're doing something to gain function and they're doing something to spread --
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2026-04-10 09:00
Ralph S. Baric
No. So you're confounding experiments. The first aim, again, is to sort of walk through this process of what makes a threat virus, how do you identify it, and how do you then try to counter that threat approach.
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With, so --
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So there were two approaches that were discussed, that were presented in that grant. One was the use of small molecule, double-stranded RNA to induce, let's call it innate immunity. These involve proteins that are induced in every one of our cells that regulate the replication and pathogen assists of viruses, and bacteria for that matter. So most people in the scientific community feel that what determines whether you live or die following a virus infection is the efficiency of inducing these innate immune molecules that regulate virus replication efficiency. And there's about 1,000 different genes that host cells make that target key steps in virus replication to knock it down. And it all starts with interferon signaling. Okay, that's the basis for it.
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But this is all under one proposal. You're saying that these were separate technical aims.
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That's correct. DC.Scheduling@LexitasLegal.com