Private channel session 1615

2 messages over 22m, 2021-09-24 – 2021-09-24.

A “conversation” here is an activity session — a run of messages with under 60 minutes of silence inside it. The channel had no native conversation boundaries.

1. 2021-09-24 13:27 Edward C. Holmes open PDF p.1006
   @Kristian Andersen On that glycosylation stuff the key comparison is actually without the BANAL or any of the viruses collected post-pandemic and perhaps even RaTG13. The key question is whether SC2 has glycosylation patterns that match those proposed in that grant (e.g. clade 2 stuff) in comparisons involving the viruses named inthat grant and known about in 2019.
2. 2021-09-24 13:50 Kristian G. Andersen open PDF p.1006
   Hey Eddie. I agree, although I think the comparisons should be to both - where SC2 matches BANAL, we 100% know it's natural. The question is, where SC2 is _different_ than BANAL, is any of that described in the grant? The answer to that is a clear no.BANAL has 23 (predicted...) N-linked glycans, SC2 has 22 - 21 of them are shared with BANAL, so SC1 has one unique N-Glycs (in the NTD), whereas BANAL has two unique N-Glycs (one in RBD, one in NTD). None of these are specifically described in the grant. Table with the N-Glycs attached. [shared file(s): N-Glycs.xlsx]