Private channel session 1103
4 messages over 18m, 2021-03-14 – 2021-03-14.
A “conversation” here is an activity session — a run of messages with under 60 minutes of silence inside it. The channel had no native conversation boundaries.
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From our nomenclature paper: https://www.nature.com/articles/s41564-020-0770-5 ```At the root of the phylogeny of SARS-CoV-2 are two lineages that we simply denote as lineages A and B. The earliest lineage A viruses, such as Wuhan/WH04/2020 (EPI_ISL_406801), sampled on 5 January 2020, share two nucleotides (positions 8,782 in ORF1ab and 28,144 in ORF8) with the closest known bat viruses (RaTG13 and RmYN02). Different nucleotides are present at those sites in viruses assigned to lineage B, of which Wuhan-Hu-1 (GenBank accession no. MN908947) sampled on 26 December 2019 is an early representative. Hence, although viruses from lineage B happen to have been sequenced and published first8,9,10, it is likely (based on current data) that the most recent common ancestor (MRCA) of the SARS-CoV-2 phylogeny shares the same genome sequenceas the early lineage A sequences (for example, Wuhan/WH04/2020). ```
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But actually the haplotype that was WA1 in Seattle (a traveller from Wuhan) is one SNP closer to the bat viruses andI think that may be the earliest sampled haplotype.
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Yes - the authors rediscovered what you already taught. The smoking raccoon dog/grate data puts this into a somewhat new context.
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https://pubmed.ncbi.nlm.nih.gov/32912998/ So this paper takes on even more significance...