Private channel session 1013

24 messages over 3h 49m, 2021-02-22 – 2021-02-22.

A “conversation” here is an activity session — a run of messages with under 60 minutes of silence inside it. The channel had no native conversation boundaries.

2021-02-22 06:22 Robert F. Garry open PDF p.538

@Kristian Andersen Nsp6 yes and the NTD mutations to. As @Andrew Rambaut has highlighted I thing the constellation of mutations converging to a common set (albeit with precise mutations somewhat variable) is key tothe "what the fuck just happened" question.
2021-02-22 06:25 Robert F. Garry open PDF p.538

Doing it right https://theconversation.com/i-was-the-australian-doctor-on-the-whos-covid-19-mission-t[...]s-what-we-found-about-the-origins-of-the-coronavirus-155554
2021-02-22 06:32 Robert F. Garry open PDF p.538

Daszak not so much, but even he should not be threatened - that's a crime and ppl like Alina are indeed culpable.One reminder about Pottinger who just did the TV interview - there is that definite connection to Peter Thiel and via Thiel to Bannon. Connecting the dots is not that hard, and by "dots" I mean $. *Conspiracy theory - you bet!* https://www.dailymail.co.uk/news/article-7090931/Tech-billionaires-Eric-Schmidt-Peter-Thiel-seen-secretive-Bilderberg-summit.html "Trump has also sent two members of the National Security Council, Matthew Turpin, Director of China and Matthew Pottinger."
2021-02-22 07:31 Robert F. Garry open PDF p.538

At least we made Yuri laugh! [shared file(s): image.png]
2021-02-22 07:33 Kristian G. Andersen open PDF p.538

I serve to please.
2021-02-22 07:35 Robert F. Garry open PDF p.539

Not clear at all who is the :clown_face:. @Kristian Andersen or the guy that will freeze your corgi's head for a fee.And, to continue my little conspiracy "theory" Yuri and Thiel it seems go way back. Yuri likely picking up another nice check for his latest tweets. Remind me when our CCP checks are coming?
2021-02-22 07:38 Kristian G. Andersen open PDF p.539

I think we just have to mention that frozen foods did it, and then the checks will come.
2021-02-22 07:39 Robert F. Garry open PDF p.539

ON it!
2021-02-22 07:56 Robert F. Garry open PDF p.539

:gorilla: [shared file(s): image.png]
2021-02-22 07:57 Robert F. Garry open PDF p.539

Don't miss it!
2021-02-22 07:57 Robert F. Garry open PDF p.539

But wasn't that zoo in San Diego?
2021-02-22 08:45 Kristian G. Andersen open PDF p.539

Yeah, San Diego... I was asked to be on that program too - but declined.
2021-02-22 08:47 Kristian G. Andersen open PDF p.539

Devi is :100: though, so I'm sure she didn't exactly intend to stir the pot of conspiracy... No doubt large-scale factoryfarming is risky from a natural emergence perspective though - but calling them "bioweapon factories" is just dumb.
2021-02-22 08:48 Andrew Rambaut open PDF p.539

You can't have a 'natural' bioweapon - by definition
2021-02-22 08:51 Kristian G. Andersen open PDF p.539

Hah, good point.
2021-02-22 08:51 Andrew Rambaut open PDF p.539

Also I don't think that a human virus getting into mink is a particularly risky think other than potentially exposing more people or creating a reservoir. It isn't going to get more human adapted.
2021-02-22 08:53 Kristian G. Andersen open PDF p.539

I don't know - having a parallel epizootic with god knows what kind of selection pressures operating is to be avoidedat all cost. Mink farming is typically also associated with other farming - creating risks of further epizootics.
2021-02-22 08:59 Andrew Rambaut open PDF p.539

I agree about the zoonosis as a route from things like bats into humans especially as these mustelids seem such good models for humans. But I just can't get excited about animal transmission as a source of variants.
2021-02-22 09:01 Andrew Rambaut open PDF p.540

Would need to be some funky epistatic interactions to get somewhere that is not readily reachable in humans in the first place.
2021-02-22 09:25 Robert F. Garry open PDF p.540

I'd like to see how Dougless and prePhil do in minks/ferrets - are they like the monkeys? Also not having mink farmsis not going to change "quality of life" for anyone except people like Ivanka and of course the mink farmers. Raise ferrets instead and let's use them to figure out better Cov/flu vaccines and drugs.
2021-02-22 09:51 Robert F. Garry open PDF p.540

@Kristian Andersen The T372A change is in the CTD, it does not likely interact with ACE2 at any level so I don't think it's in the RBD per se. Maybe this is just me. But *YES* indeed look at N519H/K [lot's of aspartic acid andhistadine mutations popping up in variants - just like in the flu adaptations btw]. Good spot @Kristian Andersen It'ssymmetrical with the T372. What are these two changes doing you might ask? If I had to guess it has to do with the"flipping up" of the CTD to better expose the RBD. Spike exists in two confirmations: closed (CTD down) and open (CTD flipped up) - it would surprising to me if both of these changes didn't favor "open." [shared file(s): image.png]
2021-02-22 10:01 Kristian G. Andersen open PDF p.540

@Kristian Andersen Ohhh, interesting. Hmmm - some functional stuff here would be cool...
2021-02-22 10:03 Robert F. Garry open PDF p.540

@Kristian Andersen Those mutations are also likely epitopes so factor that in.
2021-02-22 10:11 Robert F. Garry open PDF p.540

@Kristian Andersen BTW Yuri seems to have graduated to ClustalW, so I guess none of us stand a chance anymore.