Private channel session 986
7 messages over 1h 38m, 2021-02-17 – 2021-02-17.
A “conversation” here is an activity session — a run of messages with under 60 minutes of silence inside it. The channel had no native conversation boundaries.
-
https://www.theguardian.com/world/2021/feb/17/nicknames-emerge-for-growing-list-of-covid-variants?utm_source= dlvr.it&utm_medium=twitter
-
Q677H in 6 lineages and Q677P is the 7th. Q677P is mostly in New Mexico and Louisiana. Histidine at 677 "removes" one of the o-linked glycan predictions and decreases the "scores" of the other two. OTOH, the proline inQ677P puts in another kink near the FCS to join P681 and increases the O-linked glycan "score."
-
Would the glycan's affect the accessibility of the cleavage site to furin and thus these 677 mutations be moderating/enhancing cleavage?
-
The O-linked glycan would probably inhibit cleavage, but the extra proline kink might enhance. Either could actuallybe advantageous under certain circumstances. Example: Cleaving the FCS too soon would active the fusion process which could be "bad" for the virus in the wrong tissue or depending on timing. It's thought that viruses may have evolved the whole cleavage scheme to keep from triggering fusion during synthesis/assembly, which would obviously be "bad."
-
This from an email list: Nigeria Health Watch: A reminder that Conspiracy Theories get amplified and have real world consequences such as increasing vaccine hesitancy (are you listening Tom Frieden?) Of course the conspiracy theories regarding the China virus are being used like a club by Trump Bannon Pompeo Fox news {going hard after Fauci who "funded WIV"} - not a good look so far from Biden admin (come on Eric L]. Conspiracy theories and COVID-19 vaccine introduction in NigeriaEditor's Note: This week's piece comes from researchers Dr. Chizoba Wonodi, Chisom Obi-Jeff, Dr CarleighKrubiner, Elana Felice Jaffe, Dr. Ruth Karron, and Dr. Ruth Faden. They analyze the rise of conspiracy theories during public health crises like the current coronavirus pandemic and explore who is most vulnerable to conspiracy theories about Covid-19 vaccines and why people display vaccine hesitancy. The research is part of COVER, asix-month Wellcome-funded project led by researchers from Johns Hopkins School of Public Health andimplemented in Nigeria by Direct Consulting and Logistics.Less than 12 months after the World Health Organization (WHO) declared that the COVID-19 outbreak constituted aPublic Health Emergency of International Concern (PHEIC), there are currently 11 approved vaccines that have been administered in 75 countries, with Nigeria planning to introduce vaccines in March 2021. As of the 16thFebruary, there have been just over 108,822,960 confirmed cases, 2 million deaths and 76.69 billion USD ineconomic loss globally, the COVID-19 vaccine is the world's best shot at combating COVID-19 and returning lives and livelihood to normal. Yet, conspiracy theories (CTs) and a raging infodemic on COVID-19 and the vaccinesthreatens the vaccines' promise.What are conspiracy theories and why should they matter? Conspiracy theories reject standard explanation for events and describe them as a secret plot perpetrated byinfluential people or organizations. These theories increase during social crises or health emergencies, due touncertainties, contradictions, and psychological distress associated with the event. Image source: OrodataWhen the COVID-19 quickly spread globally, leaving mass disruption and death in its wake, people were left with many questions and few answers. Conspiracy theories emerged to fill the gaps. Fueled by the internet and social media, CTs have travelled and thrived. There are different theories about the origin of COVID-19 and speculation about the motives behind COVID-19 vaccines in Nigeria. Nearly everyone has heard one CT or another, and many people continue to be bombarded with them daily. Belief in these CTs is concerning because it threatens theadoption of COVID-19 preventive behaviours, including potential vaccine hesitancy as an obstacle to achievingadequate coverage and immunity. Conspiracy theories, fake news, and rumours about vaccines are not new in Nigeria. Their disruptive effects have previously exerted heavy financial and programmatic burden on the country. Widespread rejection of polio vaccination in Northern Nigeria in 2004 following false rumours that the vaccine sterilizes Muslim girls is still fresh inpeople's memories. It took Nigeria more than a decade of concerted effort and significant funding to overcome the vaccine hesitancy and interrupt wild polio transmission. In 2017, a false rumour about the Nigerian army injectingchildren with 'vaccines' to cause monkeypox erupted in South East Nigeria. This rumour disrupted immunizationactivities in South East Nigeria, previously known for high immunization coverage and strong vaccine demand inboth the public and private sectors. Given lessons from the polio vaccine experience, government officials, religiousleaders and respected public figures quickly restored order and trust with targeted communication and publicpersuasion. The contrast between the long-running polio rejection and short-lived monkeypox disruption highlights the notion that vaccine hesitancy can vary by source and course. It also illustrates that no program or region isimmune to direct or collateral damage from CTs and rumours. Image source: OrodataWho will be most vulnerable to conspiracy theories about COVID-19 vaccines? COVID-19 vaccines will be administered to a new cohort (adults) for whom there is limited experience on how they will accept the vaccine. Unlike the previous experience with polio and monkeypox rumours, where a single maliciousplot was linked to one vaccine or event, with COVID-19, the CTs are numerous and wide-ranging. A recent analysisby the National Primary Health Care Development Agency (NPHCDA) and Nigeria Centre for Disease Control showed CTs circulating in Nigeria about COVID-19 vaccine safety, efficacy, allocation equity, and low confidence inthe healthcare system. This begs the question, how different will COVID-19 vaccine hesitancy be compared toexperiences with other vaccines; and what new approaches are needed to tackle the problem? While exposure tothese COVID-19 CTs is almost universal, we do not know yet what proportion of the population believes them or acommon profile/characteristics of a COVID-19 CT believer. Historically, vaccine hesitancy in Nigeria has been more common among populations with low literacy and poor health outcomes. Given the role social media plays in fuelingCOVID-19 misinformation, there is not enough evidence yet to fully understand the hesitancy pattern and whether the educated population is more or less skeptical than the less-educated population. Why do people believe in conspiracy theories about COVID-19 vaccines or display hesitancy toward them? The NPHCDA has commenced periodic surveys to track trends in attitudes to COVID-19 vaccines. They have alsoinstituted rumour surveillance to identify circulating rumours and respond with the facts. These are laudable efforts that must be supported by all. However, more exploration is needed to understand why people believe in CTs and what pathways lead to vaccine hesitancy. Although this is a new research area, there is emerging evidence to show that intrinsic and extrinsic factors may explain why some people will believe in CTs about COVID-19 vaccines rather than credible information to the contrary. Recent studies have linked vaccine hesitancy to moral foundations --universal instincts that determine how people make decisions. It may be worthwhile to explore if certain moralconcerns predispose people to believe in CTs. This will complement information gleaned from standard knowledge,attitude, and practice studies and throw light on possible pathways to influencing attitudinal change even among CTbelievers.Will you take the COVID-19 vaccine when it's available in Nigeria? Trust in government is another crucial factor. Distrust in the government and vaccinations has been linked to beliefin CTs and vaccine hesitancy. A global survey found that respondents who trusted their government were more likely to accept a vaccine. Those who distrusted their governments were more likely to believe in alternative explanations for things happening. With the country's challenging economic situation and hardship exacerbated bylockdowns, there is already significant public discontent with the government, particularly handling the reliefmaterials meant to cushion the pandemic effects. Some believe COVID-19 response is another conspiracy bypoliticians to loot the treasury. This level of distrust is likely to fuel belief in CTs about the vaccine. With the COVID-19 vaccine rollout on the horizon, there is an urgent need to understand what factors may contribute to vaccine hesitancy, including moral foundations, government distrust and CT beliefs. More research isneeded to identify these factors and target them with appropriate public health messaging interventions.Current study to better understand COVID-19 vaccine conspiracy theories in Nigeria The COVID-19 Vaccine Ethics Research (COVER) in Nigeria aims to examine these issues in detail to inform communication strategies and messages that will contribute to a successful COVID-19 vaccine introduction in the country. COVER is a mixed-methods study using qualitative and quantitative approaches to better understandNigeria's CT phenomena and its link to COVID-19 vaccine acceptance. Vaccines are our best bet out of the COVID-19 outbreak and with a better understanding of the key trigger points that contribute to vaccine hesitancy, the hope is that with equitable access to vaccines and the needed supply reaching Nigeria in the short to medium term, the spread of COVID-19 can be mitigated and we all able to return to some semblance of normality In our lives.
-
@Eddie Holmes and were sent to us by the Italians on frozen fish!
-
@Robert Garry There is a tendency amongst some virologists (not the ones here, of course) to assume that any increase in kinetics automatically translates into fitter viruses. But as you say the virus needs to time the infection course just right (be maximally shedding in just the right tissue for as long as possible before symptoms onset).Everything after that is inconsequential damage caused by this.