Private channel session 791

6 messages over 32m, 2021-01-12 – 2021-01-12.

A “conversation” here is an activity session — a run of messages with under 60 minutes of silence inside it. The channel had no native conversation boundaries.

1. 2021-01-12 05:06 Robert F. Garry open PDF p.386
   One thing to consider about SC2 is that in some patients we see extremely low Ct values - 8-9 not that unusual. That converts to 2 logs higher virus load than we see with Ebola, Lassa etc. Couple that with the not well-characterized editing/proofreading functions, tendency to generate short deletions seen with MHV and others, etc and the you maybe - just maybe - start to see why a mechanism of progression of individual mutations might notbe the only pathway for evolution of CoVs.
2. 2021-01-12 05:17 Robert F. Garry open PDF p.386
   https://jvi.asm.org/content/jvi/71/4/2959.full.pdf
3. 2021-01-12 05:20 Kristian G. Andersen open PDF p.386
   That's pretty interesting - same signature
4. 2021-01-12 05:22 Robert F. Garry open PDF p.386
   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC191424/
5. 2021-01-12 05:26 Robert F. Garry open PDF p.386
   also interesting [shared file(s): image.png]
6. 2021-01-12 05:38 Robert F. Garry open PDF p.386
   I have to give a lecture at 8;30 but there is more gold to mine down this shaft...