Private channel session 440
6 messages over 39m, 2020-10-02 – 2020-10-02.
A “conversation” here is an activity session — a run of messages with under 60 minutes of silence inside it. The channel had no native conversation boundaries.
-
Very interesting and very good paper on that darn furin cleavage site. Very cool. https://www.biorxiv.org/content/10.1101/2020.09.30.318311v1 Viruses without furin cleavage site = less transmission and less pathogenic (from other studies). Makes me believe the 'pre-circulation' hypothesis of a furin site-lacking virus in humans a little more (or other animals - maybe cat-like?). It then picks up that site - which is seen in other human coronaviruses - and boom. Pandemic. Interestingly, the exact site in SARS2 is observed in some of the FIP isolates, hence a potential connection tocat-like animals. Good thread summarizing some of the findings: https://twitter.com/influenzal/status/1311959153166954498?s=20[and of course - I want to know if they virus lacking the furin site can actually pick it up after repeated passage inculture on e.g., human lung cells... :wink: ]
-
also with the cats!
-
Yes
-
Interestingly - I'm on a call with all the San Diego clinical labs at the moment. Everybody is like "WTF with those Tweets/timing last night given that the house is full of rapid tests...."
-
Maybe pass the virus on cat cells.
-
Yes - or human lung tissue cells. Bob, we need you to do this... :wink: