--- type: Conversation title: Private channel session 1415 description: "slack conversation, 50 messages, 2021-05-21." tags: - conversation - slack medium: slack message_count: 50 started_at: "2021-05-21T15:08:58" ended_at: "2021-05-21T17:22:03" duration_seconds: 7985 sources: - { id: slack_pm, resource: /sources/slack-pm.md, title: Slack / Private Message Drop, author: "process:senate-hsgac-release" } generated: { by: randpaul-corpus-pipeline/1.0, at: "2026-08-01T12:42:27Z" } status: stable --- A slack conversation of 50 messages spanning 2h 13m. # Metadata - **Started:** 2021-05-21T15:08:58 - **Ended:** 2021-05-21T17:22:03 - **Duration:** 2h 13m - **Participants:** 4 - **Source:** [slack_pm](/sources/slack-pm.md) - **Pages:** 850-854 # Participants * [Andrew Rambaut](/people/andrew-rambaut.md) * [Edward C. Holmes](/people/edward-c-holmes.md) * [Kristian G. Andersen](/people/kristian-g-andersen.md) * [Robert F. Garry](/people/robert-f-garry.md) # Transcript **[2021-05-21T15:08:58] Robert F. Garry:** https://www.sciencedirect.com/science/article/pii/S0042682219303022?via%3Dihub **[2021-05-21T15:09:04] Robert F. Garry:** https://pubmed.ncbi.nlm.nih.gov/27999425/ **[2021-05-21T15:11:17] Robert F. Garry:** https://pubmed.ncbi.nlm.nih.gov/27535067/ **[2021-05-21T15:17:06] Robert F. Garry:** Easy enough to find the research links between WIV, the wildlife rescue and Yang Guoxiang. Looks solid. Avian flu and lions! @Kristian Andersen we might use that last reference in an upcoming application. **[2021-05-21T15:41:26] Kristian G. Andersen:** Completely made up, top to bottom. Tell me this isn't 2003 all over again - WMD this time being WIV (see the resemblance.... :thinking_face:). Total crazy town. https://republicans-intelligence.house.gov/uploadedfiles/covid-19_and_the_wuhan_institute_of_virology_19_may_2 021.pdf **[2021-05-21T15:56:10] Robert F. Garry:** As Uncle Joe Biden might say this is a BFD! Here, we report the genome characterization and viral receptor analysis of a novel lineage of SARSr-CoVs in Tongguan town, Mojiang county, Yunnan province in China in 2015, the same location where we found bat RaTG13 in 2013 [1]. **[2021-05-21T15:58:40] Edward C. Holmes:** BFD. Let's hope it's published before the war starts. **[2021-05-21T15:58:46] Kristian G. Andersen:** Very interesting - I love how they totally do not drop a beat. Interesting viruses - maybe pangolins after all? I'm glad they gave Jesse his eight mysterious viruses. Turns out they weren't SARS-CoV-2 :man-shrugging: (ANY idiot would realize this if not so deep into crazy land) **[2021-05-21T15:59:23] Kristian G. Andersen:** Hybrid pangolin / mink / whatever farming happening in China? Hubei? **[2021-05-21T16:02:17] Edward C. Holmes:** Don't rule out those pangolins! Zheng-Li Shi has nerves of steel.... **[2021-05-21T16:02:18] Robert F. Garry:** Devin Nunes - - I love the tweets from his mom and his cow. **[2021-05-21T16:06:57] Edward C. Holmes:** Very much looking forward to hearing what the Bloomshitters and the Parasites will say about this.... **[2021-05-21T16:07:29] Edward C. Holmes:** @Kristian Andersen Totally fucking mental. 2003 again as you say. **[2021-05-21T16:08:02] Kristian G. Andersen:** They're going to go fucking crazy. I swear - the conspiracy theories on my Twitter timeline right now are off the chart.Total craziness. **[2021-05-21T16:11:03] Edward C. Holmes:** Yup. It's going to be great. **[2021-05-21T16:33:59] Kristian G. Andersen:** Shi's viruses - Eddie where's RmYN05 and those guys from? [shared file(s): Screen Shot 2021-05-21 at 4.33.12 PM.png] **[2021-05-21T16:34:32] Kristian G. Andersen:** Rs7896 is the new one - clade sticking out near the bottom **[2021-05-21T16:36:03] Kristian G. Andersen:** ~98% identity to those RmYN05-like viruses. Interesting. **[2021-05-21T16:36:28] Edward C. Holmes:** YN = Yunnan **[2021-05-21T16:37:41] Edward C. Holmes:** Rm = Rhinolophus malayanus **[2021-05-21T16:38:59] Edward C. Holmes:** How does the ORF1ab tree look? I usually think that is more informative. The RpYN06 paper has just been accepted in Cell. **[2021-05-21T16:39:11] Kristian G. Andersen:** shared file(s): 2021.05.21_nucleotide_genome RAxML Tree.nex, 2021.05.21_nucleotide_genome RAxML Tree.nex.pdf **[2021-05-21T16:39:20] Kristian G. Andersen:** I have a sim plot - lemme share **[2021-05-21T16:40:03] Kristian G. Andersen:** ORF1ab similar. Let me make a tree [shared file(s): simplot.pdf] **[2021-05-21T16:40:10] Kristian G. Andersen:** (similar to the Rm ones) **[2021-05-21T16:41:15] Kristian G. Andersen:** Black line is the new one **[2021-05-21T16:41:26] Andrew Rambaut:** @Kristian Andersen What's this tree? Complete genomes? **[2021-05-21T16:42:08] Kristian G. Andersen:** @Kristian Andersen Yeah **[2021-05-21T16:42:47] Kristian G. Andersen:** @Kristian Andersen Here's a nicely formatted/annotated alignment [shared file(s): 2021.05.21_nucleotide_genome.geneious] **[2021-05-21T16:43:26] Edward C. Holmes:** Thanks! **[2021-05-21T16:43:29] Andrew Rambaut:** Sorry - it is too late for simplots and recombination. Will take a look tomorrow **[2021-05-21T16:43:47] Kristian G. Andersen:** No kidding. Good night! **[2021-05-21T16:44:10] Kristian G. Andersen:** (I shared the full alignment in the thread - so you have that for tomorrow. All CDS annotated) **[2021-05-21T16:44:45] Edward C. Holmes:** Hope the bioRxiv post goes up soon :bomb: **[2021-05-21T16:44:55] Kristian G. Andersen:** COME ON ALREADY!! **[2021-05-21T16:47:09] Andrew Rambaut:** Post the good tweets here for reading over coffee... **[2021-05-21T16:48:04] Kristian G. Andersen:** N/A **[2021-05-21T16:48:29] Kristian G. Andersen:** Spike and ORF1ab trees - note these are midpoint rooted, because I have no idea how to root these guys. [shared file(s): 2021.05.21_nucleotide_Spike RAxML Tree.nex.pdf, 2021.05.21_nucleotide_Spike RAxML Tree.nex, 2021.05.21_nucleotide_ORF1ab RAxML Tree.nex.pdf, 2021.05.21_nucleotide_ORF1ab RAxML Tree.nex] **[2021-05-21T16:49:22] Kristian G. Andersen:** Paper is online - https://www.biorxiv.org/content/10.1101/2021.05.21.445091v1 **[2021-05-21T16:50:48] Edward C. Holmes:** Let the show begin... **[2021-05-21T16:52:31] Kristian G. Andersen:** Eddie, the lab leak theory isn't a conspiracy theory, you know? Just so that's clear... **[2021-05-21T16:53:08] Edward C. Holmes:** Sorry, I keep forgetting... **[2021-05-21T16:53:46] Kristian G. Andersen:** I know. It's easy to forget. Separately - fucking hell, these viruses - SO MUCH DIVERSITY!!!!!!!!!! **[2021-05-21T16:59:36] Edward C. Holmes:** Indeed. Doesn't take much to think that any particular RBD+FCS combination could arise. Nature does it again. **[2021-05-21T17:16:18] Kristian G. Andersen:** Nah. I had bookmarked that BioProject previously so I just came across it. **[2021-05-21T17:16:52] Edward C. Holmes:** Ah yes, I remember now. **[2021-05-21T17:17:24] Kristian G. Andersen:** But yeah - I _could_ have waited ten minutes... Others found the paper before me though **[2021-05-21T17:18:34] Edward C. Holmes:** Jonathan Eisen is a stand-up guy on this. **[2021-05-21T17:19:05] Kristian G. Andersen:** He is. He's able to keep a cool head. **[2021-05-21T17:22:03] Edward C. Holmes:** WIV are in an impossible position: don't release the data and they are accused of hiding it, release it and they are accused of faking it. Having no PCR/antibody positives at the WIV and they are accused of lying, having n = 1 caseat WIV then that would be patient zero.