---
type: Conversation
title: Private channel session 862
description: "slack conversation, 17 messages, 2021-01-23."
tags:
  - conversation
  - slack
medium: slack
message_count: 17
started_at: "2021-01-23T13:20:37"
ended_at: "2021-01-23T15:28:56"
duration_seconds: 7699
sources:
  - { id: slack_pm, resource: /sources/slack-pm.md, title: Slack / Private Message Drop, author: "process:senate-hsgac-release" }
generated: { by: randpaul-corpus-pipeline/1.0, at: "2026-08-01T12:42:27Z" }
status: stable
---

A slack conversation of 17 messages spanning 2h 8m.

# Metadata

- **Started:** 2021-01-23T13:20:37
- **Ended:** 2021-01-23T15:28:56
- **Duration:** 2h 8m
- **Participants:** 4
- **Source:** [slack_pm](/sources/slack-pm.md)
- **Pages:** 441-442

# Participants

* [Andrew Rambaut](/people/andrew-rambaut.md)
* [Edward C. Holmes](/people/edward-c-holmes.md)
* [Kristian G. Andersen](/people/kristian-g-andersen.md)
* [Robert F. Garry](/people/robert-f-garry.md)

# Transcript

**[2021-01-23T13:20:37] Edward C. Holmes:** @Robert Garry The sequence of the Cambodian bat virus is now on GISAID. Not sure if you have it. Also, do you/we plan to write-up these Virological posts into a paper? Things are moving quickly though.

**[2021-01-23T13:39:31] Andrew Rambaut:** More seriously - what would be the optimal FCS?

**[2021-01-23T13:41:08] Andrew Rambaut:** And of course optimal cleavage may not have peak fitness benefit to the virus - you can presumably cleave too well and alter some other trade off in the dynamics.

**[2021-01-23T14:28:36] Andrew Rambaut:** Genomes - England per day. Red = B.1.1.7, Blue = B.1.177, Grey = the rest [shared file(s): image.png]

**[2021-01-23T14:36:56] Edward C. Holmes:** Just going through my emails for the GIPA crap. Some are poignant. [shared file(s): Screen Shot 2021-01-24 at 9.27.27 am.png]

**[2021-01-23T14:37:41] Edward C. Holmes:** Note the date

**[2021-01-23T14:40:43] Andrew Rambaut:** Will these be made public?

**[2021-01-23T14:46:28] Edward C. Holmes:** No plans to. They don't directly relate to the paper.

**[2021-01-23T14:51:55] Robert F. Garry:** @Andrew Rambaut Agree with this - optimal cleavage might vary depending on multiple factors - cleave in the wrong tissue or wrong time not good. - An optimal cleavage site is RRXRR. Not all X's equal so RRRRR among the best.

**[2021-01-23T14:52:01] Edward C. Holmes:** But I can of course use them if necessary.

**[2021-01-23T14:53:21] Andrew Rambaut:** True - would be interesting if some of that got out (doesn't look good for CCDC)

**[2021-01-23T14:54:18] Edward C. Holmes:** Oh no.

**[2021-01-23T14:57:12] Robert F. Garry:** Wow.

**[2021-01-23T14:58:25] Robert F. Garry:** "Also, do you/we plan to write-up these Virological posts into a paper?" yes - needed! on it.

**[2021-01-23T15:05:30] Kristian G. Andersen:** Whoa Eddie - that's pretty scary language in that email.

**[2021-01-23T15:28:24] Edward C. Holmes:** Yes, very bad. You know, all the bad stuff that came out of this, all the attacks that are ongoing, are due to George Gao. No doubt.

**[2021-01-23T15:28:56] Edward C. Holmes:** Thanks for working on the paper Bob!